Predicting properties of intrinsically unstructured proteins
نویسندگان
چکیده
منابع مشابه
Structural analysis of intrinsically unstructured proteins using Raman optical activity
A major obstacle in the structural analysis of intrinsically unstructured proteins (IUPs), at least from a classical biological perspective, is precisely that: lack of structure. While the dynamic nature of IUPs makes crystallographic studies virtually impossible, even solution based NMR studies of this group of proteins are difficult, due to the fast, fluid changes in back bone torsion angles....
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Most proteins function only when folded into a particular 3D configuration. Recently, a class of proteins has been discovered that do not fold into any particular configuration; these are known as Intrinsically Unstructured (IU) proteins. We construct a classifier to identify IU regions in proteins based on features derived from protein sequence information alone, and evaluate it on out-of-samp...
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A major challenge in the post-genome era will be determination of the functions of the encoded protein sequences. Since it is generally assumed that the function of a protein is closely linked to its three-dimensional structure, prediction or experimental determination of the library of protein structures is a matter of high priority. However, a large proportion of gene sequences appear to code...
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Intrinsically disordered/unstructured proteins exist without a stable three-dimensional (3D) structure as highly flexible conformational ensembles. The available genome sequences revealed that these proteins are surprisingly common and their frequency reaches high proportions in eukaryotes. Due to their vital role in various biological processes including signaling and regulation and their invo...
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ژورنال
عنوان ژورنال: Progress in Biophysics and Molecular Biology
سال: 2001
ISSN: 0079-6107
DOI: 10.1016/s0079-6107(01)00012-8